Molecular characterization of dilated cardiomyopathy

Histologic characterization of canine dilated cardiomyopathy.

Dilated cardiomyopathy (DCM), characterized by chamber dilatation and myocardial systolic and diastolic dysfunction, is one of the most common heart diseases in dogs. The clinical diagnosis is based on findings on echocardiographic and Doppler examinations, with the active exclusion of other acquired or congenital heart diseases. However, the echocardiographic criteria for the diagnosis of DCM ...

Genetics of dilated cardiomyopathy: a molecular maze?

Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by ventricular dilatation and impaired systolic function, and is a major cause of severe heart failure. Although familial occurrence of DCM has been reported occasionally, the frequency of familial aetiology has been underestimated in the past. Systematic examination of relatives show that probably > 25–30% of DCM cases are fa...

Dilated Cardiomyopathy

Dilated cardiomyopathy.

Dilated Cardiomyopathy

Background. Immunization with cardiac myosin induces experimental autoimmune heart disease in genetically predisposed mice. These mice produce heart-specific autoantibodies, some of which are directed against the cardiac myosin isoform. Methods and Results. We have reported the presence of circulating heart-specific autoantibodies in 26% of patients with idiopathic dilated cardiomyopathy (DCM) ...